Protein engineering aims obtaining improved molecules to enhance the clinical efficiency, manufacturability and reduce the immunogenicity of a promising clinic candidate. This is achieved by recombinant DNA technology to change their amino acid sequences.
Rodon Biologics has long-term dedicated to protein engineering, offering a range of standard and custom packages. Our services based on rational design intends to improve protein stability, affinity kinetics, solubility, manufacturability, and activity.
We offer a complete portfolio of protein engineering related services such as DNA sequence design, high-throughput protein expression and purification and appropriate functional assays.
Furthermore, we are specialized in antibody engineering offering services in isotype switching, humanisation and manufacturing of recombinant antibody fragments and multispecific antibodies formats. At Rodon we developed techniques that allow reformatting antibodies into different formats. This next generation of complex biologics with new mechanisms of action may result in a clinic candidate with a higher efficiency and safety. Alternatively, antibody fragments may also offer an alternative to full-length antibodies, either for clinical application or for safety testing. Thanks to our antibody engineering platform we can produce and purify antibody fragments such as Fv (scFv), Fab or Fab2.
The complexity of new antibody based format can create manufacturability and product quality challenges. Thanks to Rodon’s vast experience, expertise and flexibility with multivalent antibodies and complex recombinant proteins, the protein engineering programmes are design from a manufacturability standpoint and are performed based on our production platform.
We Offer More
Looking for additional services? We offer even more services than listed, contact us to find out how we can assist you. Using latest advances in Protein Technologies Rodon Biologics strives to provide the highest quality custom protein services in the industry. We work closely with you, analyze your project at the planning stage and take several approaches to ensure you get the results you are looking for.Know More